Local adrenomedullin gene delivery inhibits Leydig cell dysfunction by rescuing steroidogenic enzymes in vivo.

Zhou, Jian-Hua; Zhu, Xia-Lian; Li, Ming-Yong; Luo, You-Wen; Yang, Zhi-Min; Wang, Li; Tong, Tao; Qin, Song-Lin; Liu, Bo-Long; Chen, Bing-Hai; Hu, Wei.

Affiliation

Zhou JH; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Zhu XL; Department of Nuclear Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Li MY; Department of Urology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Luo YW; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Yang ZM; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Wang L; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Tong T; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Qin SL; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Liu BL; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Chen BH; Department of Urology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Hu W; Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Andrologia ; 54(10): e14545, 2022 Nov.

Article in En | MEDLINE | ID: mdl-35942817

Subject(s)

Leydig Cells; Lyases; 3-Hydroxysteroid Dehydrogenases/metabolism; Adrenomedullin/genetics; Adrenomedullin/metabolism; Adrenomedullin/pharmacology; Animals; Cholesterol Side-Chain Cleavage Enzyme/genetics; Cholesterol Side-Chain Cleavage Enzyme/metabolism; Lipopolysaccharides/metabolism; Lipopolysaccharides/pharmacology; Lyases/metabolism; Lyases/pharmacology; Male; Phosphoproteins/genetics; Phosphoproteins/metabolism; Rats; Steroid 17-alpha-Hydroxylase/genetics; Steroid 17-alpha-Hydroxylase/metabolism; Steroid 17-alpha-Hydroxylase/pharmacology; Testosterone

Key words

adrenomedullin; leydig cell; lipopolysaccharide; steroidogenic enzyme