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CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.
Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; Fan, Yannan; Ahuja, Karan; Moisse, Matthieu; Jacquemyn, Maarten; Furtado Madeiro da Costa, Rodrigo; Gajjar, Madhavsai; Balusu, Sriram; Tricot, Tine; Fumagalli, Laura; Hersmus, Nicole; Janky, Rekin's; Impens, Francis; Vanden Berghe, Pieter; Ho, Ritchie; Thal, Dietmar Rudolf; Vandenberghe, Rik; Hegde, Muralidhar L; Chandran, Siddharthan; De Strooper, Bart; Daelemans, Dirk; Van Damme, Philip; Van Den Bosch, Ludo; Verfaillie, Catherine.
Affiliation
  • Guo W; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • Wang H; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Kumar Tharkeshwar A; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Couthouis J; Division of DNA Repair Research, Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, Texas, USA.
  • Braems E; Department of Neuroscience Research at Neurological Surgery, Weill Medical College, New York, New York, USA.
  • Masrori P; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Van Schoor E; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Fan Y; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
  • Ahuja K; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Moisse M; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Jacquemyn M; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Furtado Madeiro da Costa R; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Gajjar M; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Balusu S; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Tricot T; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Fumagalli L; Laboratory of Neuropathology, Department of Imaging and Pathology, KU Leuven, and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Hersmus N; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • Janky R; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • Impens F; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Vanden Berghe P; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Ho R; KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.
  • Thal DR; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • Vandenberghe R; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • Hegde ML; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Chandran S; Stem Cell Institute, Department of Devolpment and Regeneration, KU Leuven, Leuven, Belgium.
  • De Strooper B; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Daelemans D; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Van Damme P; Department of Neurosciences, Experimental Neurology, Laboratory of Neurobiology, KU Leuven-University of Leuven, Leuven, Belgium.
  • Van Den Bosch L; VIB, Center for Brain & Disease Research, Leuven, Belgium and Leuven Brain Institute (LBI), Leuven, Belgium.
  • Verfaillie C; VIB Nucleomics Core, Leuven, Belgium.
Alzheimers Dement ; 19(4): 1245-1259, 2023 04.
Article in En | MEDLINE | ID: mdl-35993441
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Full text: 1 Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Animals / Humans Language: En Year: 2023 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Animals / Humans Language: En Year: 2023 Type: Article