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The role of IgA in gastrointestinal helminthiasis: A systematic review.
Ramos, Anne C S; Oliveira, Luciana M; Santos, Yvanna L D C O; Dantas, Marlon C S; Walker, Cristiani I B; Faria, Ana M C; Bueno, Lílian L; Dolabella, Silvio S; Fujiwara, Ricardo T.
Affiliation
  • Ramos ACS; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil.
  • Oliveira LM; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil; Departamento de Morfologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil.
  • Santos YLDCO; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil.
  • Dantas MCS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil.
  • Walker CIB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil.
  • Faria AMC; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, MG, Brasil.
  • Bueno LL; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, MG, Brasil.
  • Dolabella SS; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil. Electronic address: dolabellaufs@gmail.com.
  • Fujiwara RT; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão 49100-000, SE, Brasil; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, MG, Brasil. Electronic address: fujiwara@icb.ufmg
Immunol Lett ; 249: 12-22, 2022 09.
Article in En | MEDLINE | ID: mdl-36002066
ABSTRACT
Immunoglobulin-A (IgA) is an important mediator of immunity and has been associated with protection against several pathogens, although its role in gastrointestinal infections remains unclear. Then, the aim of this systematic review was to synthesize qualitative evidence in respect of IgA as mediator of protective immunity against gastrointestinal helminths. Following recommended guidelines, we searched for articles published between January 1990 and October 2019 that evaluated IgA levels and their association with gastrointestinal helminth infections. Twenty-five articles were included after screening 1,546 titles and abstracts, as well as reading in full 52 selected articles. Consistent associations between higher IgA levels and lower parasitological parameters were only found in mice, rats, and sheep. However, the role of IgA in other host species remains uncertain, making it difficult to create a consensus. Therefore, it is too soon to claim that IgA is an effective protective factor against gastrointestinal helminths, and further studies are still needed.
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin A / Helminthiasis Type of study: Qualitative_research / Systematic_reviews Limits: Animals Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin A / Helminthiasis Type of study: Qualitative_research / Systematic_reviews Limits: Animals Language: En Year: 2022 Type: Article