Quantifying Chromosome Structural Reorganizations during Differentiation, Reprogramming, and Transdifferentiation.
Phys Rev Lett
; 129(6): 068102, 2022 Aug 05.
Article
in En
| MEDLINE
| ID: mdl-36018639
ABSTRACT
We developed a nonequilibrium model to study chromosome structural reorganizations within a simplified cell developmental system. From the chromosome structural perspective, we predicted that the neural progenitor cell is on the neural developmental path and very close to the transdifferentiation path from the fibroblast to the neuron cell. We identified an early bifurcation of stem cell differentiation processes and the cell-of-origin-specific reprogramming pathways. Our theoretical results are in good agreement with available experimental evidence, promoting future applications of our approach.
Full text:
1
Database:
MEDLINE
Main subject:
Cell Transdifferentiation
/
Fibroblasts
Type of study:
Prognostic_studies
Language:
En
Year:
2022
Type:
Article