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Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.
Najjar, Abdulkarim; Punt, Ans; Wambaugh, John; Paini, Alicia; Ellison, Corie; Fragki, Styliani; Bianchi, Enrica; Zhang, Fagen; Westerhout, Joost; Mueller, Dennis; Li, Hequn; Shi, Quan; Gant, Timothy W; Botham, Phil; Bars, Rémi; Piersma, Aldert; van Ravenzwaay, Ben; Kramer, Nynke I.
Affiliation
  • Najjar A; Beiersdorf AG, Hamburg, Germany.
  • Punt A; Wageningen Food Safety Research, Wageningen, The Netherlands.
  • Wambaugh J; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
  • Paini A; esqLABS GmbH, Saterland, Germany.
  • Ellison C; The Procter and Gamble Company, Cincinnati, OH, USA.
  • Fragki S; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Bianchi E; Corteva Agriscience, Indianapolis, IN, USA.
  • Zhang F; The Dow Chemical Company, Midland, MI, USA.
  • Westerhout J; The Netherlands Organisation for Applied Scientific Research TNO, Utrecht, The Netherlands.
  • Mueller D; Research and Development, Crop Science, Bayer AG, Monheim, Germany.
  • Li H; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK.
  • Shi Q; Shell Global Solutions International B.V, The Hague, The Netherlands.
  • Gant TW; School of Public Health, Faculty of Medicine, Imperial College London, London, UK.
  • Botham P; Syngenta, Jealott's Hill, Bracknell, Berkshire, UK.
  • Bars R; Crop Science Division, Bayer S.A.S., Sophia Antipolis, France.
  • Piersma A; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van Ravenzwaay B; Environmental Sciences Consulting, Altrip, Germany.
  • Kramer NI; Toxicology Division, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands. nynke.kramer@wur.nl.
Arch Toxicol ; 96(12): 3407-3419, 2022 12.
Article in En | MEDLINE | ID: mdl-36063173
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Full text: 1 Database: MEDLINE Main subject: Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Year: 2022 Type: Article