The glycocalyx as a permeability barrier: basic science and clinical evidence.
Crit Care
; 26(1): 273, 2022 09 12.
Article
in En
| MEDLINE
| ID: mdl-36096866
ABSTRACT
Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in plasma mostly originate from 99.6-99.8% of the endothelial surface not involved in transendothelial passage of water and proteins. Fragment concentrations correlate poorly with in vivo imaging of glycocalyx thickness, and calculations of expected glycocalyx resistance are incompatible with measured hydraulic conductivity values. Increases in plasma breakdown products in rats did not correlate with vascular permeability. Clinically, three studies in humans show inverse correlations between glycocalyx degradation products and the capillary leakage of albumin and fluid.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Capillary Permeability
/
Glycocalyx
Limits:
Animals
/
Humans
Language:
En
Year:
2022
Type:
Article