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Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis.
Barry, Robert L; Torrado-Carvajal, Angel; Kirsch, John E; Arabasz, Grae E; Albrecht, Daniel S; Alshelh, Zeynab; Pijanowski, Olivia; Lewis, Austin J; Keegan, Mackenzie; Reynolds, Beverly; Knight, Paulina C; Morrissey, Erin J; Loggia, Marco L; Atassi, Nazem; Hooker, Jacob M; Babu, Suma.
Affiliation
  • Barry RL; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, USA. Ele
  • Torrado-Carvajal A; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain.
  • Kirsch JE; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Arabasz GE; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Albrecht DS; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Alshelh Z; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Pijanowski O; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.
  • Lewis AJ; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.
  • Keegan M; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.
  • Reynolds B; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.
  • Knight PC; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.
  • Morrissey EJ; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Loggia ML; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA,
  • Atassi N; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Sanofi Genzyme, Cambridge, MA, USA.
  • Hooker JM; Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Babu S; Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: sbabu@mgh.Harvard.edu.
Neuroimage Clin ; 36: 103199, 2022.
Article in En | MEDLINE | ID: mdl-36137496
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disorder affecting motor neurons in the spinal cord and brain. Studies have reported on atrophy within segments of the cervical cord, but we are not aware of previous investigations of the whole spinal cord. Herein we present our findings from a 3T MRI study involving 32 subjects (15 ALS participants and 17 healthy controls) characterizing cross-sectional area along the entire cord. We report atrophy of the cervical enlargement in ALS participants, but no evidence of atrophy of the thoracolumbar enlargement. These results suggest that MR-based analyses of the cervical cord may be sufficient for in vivo investigations of spinal cord atrophy in ALS, and that atrophy of the cervical enlargement (C4-C7) is a potential imaging marker for quantifying lower motor neuron degradation.
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Full text: 1 Database: MEDLINE Main subject: Cervical Cord / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Cervical Cord / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Year: 2022 Type: Article