Avoiding Systematic Bias in Orthopedics Research Through Informed Variable Selection: A Discussion of Confounders, Mediators, and Colliders.
J Arthroplasty
; 37(10): 1951-1955, 2022 10.
Article
in En
| MEDLINE
| ID: mdl-36162928
ABSTRACT
There are 3 common variable types in orthopedic research-confounders, colliders, and mediators. All 3 types of variables are associated with both the exposure (eg, surgery type, implant type, body mass index) and outcome (eg, complications, revision surgery) but differ in their temporal ordering. To reduce systematic bias, the decision to include or exclude a variable in an analysis should be based on the variable's relationship with the exposure and outcome for each research question. In this article, we define 3 types of variables with case examples from orthopedic research. Please visit the followinghttps//youtu.be/V-grpgB1ShQfor videos that explain the highlights of the article in practical terms.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Orthopedics
/
Orthopedic Procedures
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2022
Type:
Article