Transcriptomic Profiling Identifies CD8<sup>+</sup> T Cells in the Brain of Aged and Alzheimer's Disease Transgenic Mice as Tissue-Resident Memory T Cells.

Altendorfer, Barbara; Unger, Michael Stefan; Poupardin, Rodolphe; Hoog, Anna; Asslaber, Daniela; Gratz, Iris Karina; Mrowetz, Heike; Benedetti, Ariane; de Sousa, Diana Marisa Bessa; Greil, Richard; Egle, Alexander; Gate, David; Wyss-Coray, Tony; Aigner, Ludwig

Transcriptomic Profiling Identifies CD8⁺ T Cells in the Brain of Aged and Alzheimer's Disease Transgenic Mice as Tissue-Resident Memory T Cells.

Altendorfer, Barbara; Unger, Michael Stefan; Poupardin, Rodolphe; Hoog, Anna; Asslaber, Daniela; Gratz, Iris Karina; Mrowetz, Heike; Benedetti, Ariane; de Sousa, Diana Marisa Bessa; Greil, Richard; Egle, Alexander; Gate, David; Wyss-Coray, Tony; Aigner, Ludwig.

Affiliation

Altendorfer B; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
Unger MS; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
Poupardin R; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
Hoog A; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
Asslaber D; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
Gratz IK; Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria.
Mrowetz H; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
Benedetti A; Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria.
de Sousa DMB; IIIrd Medical Department with Hematology and Medical Oncology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.
Greil R; Salzburg Cancer Research Institute with Laboratory of Immunological and Molecular Cancer Research and Center for Clinical Cancer and Immunology Trials, Salzburg, Austria.
Egle A; Cancer Cluster Salzburg, Salzburg, Austria.
Gate D; Department of Biosciences, University of Salzburg, Salzburg, Austria.
Wyss-Coray T; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
Aigner L; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.

J Immunol ; 209(7): 1272-1285, 2022 10 01.

Article in En | MEDLINE | ID: mdl-36165202

Subject(s)

Alzheimer Disease; Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Animals; Brain; CD8-Positive T-Lymphocytes; Disease Models, Animal; Memory T Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Presenilin-1/genetics; Transcriptome

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