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Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation.
Kim, Tae-Eun; Tsuboyama, Kotaro; Houliston, Scott; Martell, Cydney M; Phoumyvong, Claire M; Lemak, Alexander; Haddox, Hugh K; Arrowsmith, Cheryl H; Rocklin, Gabriel J.
Affiliation
  • Kim TE; Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
  • Tsuboyama K; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
  • Houliston S; Center for Synthetic Biology, Northwestern University, Evanston, IL 60208.
  • Martell CM; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
  • Phoumyvong CM; Center for Synthetic Biology, Northwestern University, Evanston, IL 60208.
  • Lemak A; PRESTO, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0076, Japan.
  • Haddox HK; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Arrowsmith CH; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada.
  • Rocklin GJ; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
Proc Natl Acad Sci U S A ; 119(41): e2122676119, 2022 10 11.
Article in En | MEDLINE | ID: mdl-36191185
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Full text: 1 Database: MEDLINE Main subject: Proteins / Protein Folding Language: En Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Proteins / Protein Folding Language: En Year: 2022 Type: Article