Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8.

Wang, Xiaocong; Hanes, Melinda S; Cummings, Richard D; Woods, Robert J

Wang, Xiaocong; Hanes, Melinda S; Cummings, Richard D; Woods, Robert J.

Affiliation

Wang X; Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Hanes MS; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602.
Cummings RD; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.
Woods RJ; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.

Proc Natl Acad Sci U S A ; 119(41): e2117743119, 2022 10 11.

Article in En | MEDLINE | ID: mdl-36191232

Subject(s)

E-Selectin; Oligosaccharides; E-Selectin/genetics; Ligands; Oligosaccharides/chemistry; Polysaccharides/metabolism; Sialic Acid Binding Immunoglobulin-like Lectins; Sialyl Lewis X Antigen; Sulfates/metabolism

Key words

GLYCAM; glycan microarray screening; lectin engineering; rational protein design; sulfated oligosaccharide

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