Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.

Kaye, Keith S; Belley, Adam; Barth, Philip; Lahlou, Omar; Knechtle, Philipp; Motta, Paola; Velicitat, Patrick

Kaye, Keith S; Belley, Adam; Barth, Philip; Lahlou, Omar; Knechtle, Philipp; Motta, Paola; Velicitat, Patrick.

Affiliation

Kaye KS; Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Belley A; Allecra Therapeutics SAS, St Louis, France.
Barth P; Allecra Therapeutics SAS, St Louis, France.
Lahlou O; Allecra Therapeutics SAS, St Louis, France.
Knechtle P; now with discoveric bio beta Ltd, Pfäffikon SZ, Switzerland.
Motta P; now with Spexis Ltd, CH-4123 Allschwil, Switzerland.
Velicitat P; Allecra Therapeutics SAS, St Louis, France.

JAMA ; 328(13): 1304-1314, 2022 10 04.

Article in En | MEDLINE | ID: mdl-36194218

Subject(s)

Anti-Bacterial Agents; Cefepime; Piperacillin, Tazobactam Drug Combination; Pyelonephritis; Urinary Tract Infections; beta-Lactamase Inhibitors; Acute Disease; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/adverse effects; Anti-Bacterial Agents/therapeutic use; Cefepime/administration & dosage; Cefepime/adverse effects; Cefepime/therapeutic use; Double-Blind Method; Drug Combinations; Female; Gram-Negative Bacterial Infections/drug therapy; Humans; Infusions, Intravenous; Male; Middle Aged; Piperacillin, Tazobactam Drug Combination/administration & dosage; Piperacillin, Tazobactam Drug Combination/adverse effects; Piperacillin, Tazobactam Drug Combination/therapeutic use; Pyelonephritis/drug therapy; Pyelonephritis/microbiology; Urinary Tract Infections/complications; Urinary Tract Infections/drug therapy; Urinary Tract Infections/microbiology; beta-Lactamase Inhibitors/administration & dosage; beta-Lactamase Inhibitors/adverse effects; beta-Lactamase Inhibitors/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Pyelonephritis / Urinary Tract Infections / Beta-Lactamase Inhibitors / Cefepime / Piperacillin, Tazobactam Drug Combination / Anti-Bacterial Agents Type of study: Clinical_trials / Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Year: 2022 Type: Article

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