Monocyte exposure to fine particulate matter results in miRNA release: A link between air pollution and potential clinical complication.
Environ Toxicol Pharmacol
; 96: 103996, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-36228992
ABSTRACT
Chronic exposure to PM2.5 contributes to the pathogenesis of numerous disorders, although the underlying mechanisms remain unknown. The study investigated whether exposure of human monocytes to PM2.5 is associated with alterations in miRNAs. Monocytes were exposed in vitro to PM2.5 collected during winter and summer, followed by miRNA isolation from monocytes. Additionally, in 140 persons chronically exposed to air pollution, some miRNA patterns were isolated from serum seasonally. Between-season differences in chemical PM2.5 composition were observed. Some miRNAs were expressed both in monocytes and in human serum. MiR-34c-5p and miR-223-5p expression was more pronounced in winter. Bioinformatics analyses showed that selected miRNAs were involved in the regulation of several pathways. The expression of the same miRNA species in monocytes and serum suggests that these cells are involved in the production of miRNAs implicated in the development of disorders mediated by inflammation, oxidative stress, proliferation, and apoptosis after exposure to PM2.5.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
MicroRNAs
/
Air Pollutants
/
Air Pollution
Limits:
Humans
Language:
En
Year:
2022
Type:
Article