New polyketides from the basidiomycetous fungus <i>Pholiota</i> sp.

Lin, Jie; Huo, Rui-Yun; Hou, Lin; Jiang, Shan; Wang, Shu-Lin; Deng, Yan-Ling; Liu, Ling

New polyketides from the basidiomycetous fungus Pholiota sp.

Lin, Jie; Huo, Rui-Yun; Hou, Lin; Jiang, Shan; Wang, Shu-Lin; Deng, Yan-Ling; Liu, Ling.

Affiliation

Lin J; Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.
Huo RY; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Hou L; University of Chinese Academy of Sciences, Beijing 100039, China.
Jiang S; Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.
Wang SL; Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.
Deng YL; Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.
Liu L; Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.

J Asian Nat Prod Res ; 25(7): 674-682, 2023.

Article in En | MEDLINE | ID: mdl-36250229

ABSTRACT

ABSTRACT

Two new polyketides, pholiotones B and C (1 and 2), and four known compounds, trichodermatide D (3), vermistatin (4), dehydroaltenuene A (5) and terpestacin (6) were isolated from the crude extract of Pholiota sp. Their structures were identified by NMR and MS spectroscopic data. The absolute configurations of compounds 1 and 2 were elucidated by modified Mosher's method, electronic circular dichroism (ECD) calculations and 13C NMR calculations as well as DP4+ probability analyses. All the compounds were evaluated for their antifungal and cytotoxicity.

Subject(s)

Pholiota; Polyketides; Molecular Structure; Polyketides/chemistry; Magnetic Resonance Spectroscopy; Antifungal Agents/chemistry

Key words

Pholiota sp.; biological activities; structure elucidation

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