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Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
Nye, Taylor M; Tükenmez, Hasan; Singh, Pardeep; Flores-Mireles, Ana L; Obernuefemann, Chloe L P; Pinkner, Jerome S; Sarkar, Souvik; Bonde, Mari; Lindgren, Anders E G; Dodson, Karen W; Johansson, Jörgen; Almqvist, Fredrik; Caparon, Michael G; Hultgren, Scott J.
Affiliation
  • Nye TM; Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110-1093.
  • Tükenmez H; Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
  • Singh P; Department of Molecular Biology, Umeå University, SE-90187 Umeå, Sweden.
  • Flores-Mireles AL; Umeå Centre for Microbial Research, UCMR, Umeå University, SE-90187 Umeå, Sweden.
  • Obernuefemann CLP; Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
  • Pinkner JS; Umeå Centre for Microbial Research, UCMR, Umeå University, SE-90187 Umeå, Sweden.
  • Sarkar S; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN.
  • Bonde M; Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110-1093.
  • Lindgren AEG; Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110-1093.
  • Dodson KW; Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
  • Johansson J; Umeå Centre for Microbial Research, UCMR, Umeå University, SE-90187 Umeå, Sweden.
  • Almqvist F; Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
  • Caparon MG; QureTech Bio, Umeå, Sweden.
  • Hultgren SJ; Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
Proc Natl Acad Sci U S A ; 119(43): e2210912119, 2022 10 25.
Article in En | MEDLINE | ID: mdl-36252016
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Full text: 1 Database: MEDLINE Main subject: Pyridones / Vancomycin-Resistant Enterococci / Gram-Positive Bacteria Language: En Year: 2022 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyridones / Vancomycin-Resistant Enterococci / Gram-Positive Bacteria Language: En Year: 2022 Type: Article