Phospholipid imbalance impairs autophagosome completion.

Polyansky, Alexandra; Shatz, Oren; Fraiberg, Milana; Shimoni, Eyal; Dadosh, Tali; Mari, Muriel; Reggiori, Fulvio M; Qin, Chao; Han, Xianlin; Elazar, Zvulun

Polyansky, Alexandra; Shatz, Oren; Fraiberg, Milana; Shimoni, Eyal; Dadosh, Tali; Mari, Muriel; Reggiori, Fulvio M; Qin, Chao; Han, Xianlin; Elazar, Zvulun.

Affiliation

Polyansky A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Shatz O; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Fraiberg M; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Shimoni E; Department of Chemical Research Support, The Weizmann Institute of Science, Rehovot, Israel.
Dadosh T; Department of Chemical Research Support, The Weizmann Institute of Science, Rehovot, Israel.
Mari M; Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Reggiori FM; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Qin C; Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Han X; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Elazar Z; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

EMBO J ; 41(23): e110771, 2022 12 01.

Article in En | MEDLINE | ID: mdl-36300838

Subject(s)

Autophagosomes; Phospholipids; Autophagosomes/metabolism; Phospholipids/metabolism; Autophagy-Related Proteins/metabolism; Autophagy; Choline/metabolism; Cytidine Diphosphate/metabolism

Key words

autophagosome biogenesis; autophagy; phagophore; phospholipids

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