Spontaneous Escherichia coli Meningitis and Pyogenic Ventriculitis in an Adult Receiving Anti-Tumour Necrosis Factor Alpha Therapy.

Hare, D; Doyle, D; Doherty, A; Creedon, M; Houlihan, E; Harrison, M; Sheppard, D; Fleming, C; Fitzpatrick, F; Cormican, M.

Affiliation

Hare D; Department of Clinical Microbiology, Galway University Hospital, Galway, Ireland.
Doyle D; Department of Respiratory Medicine, Galway University Hospital, Galway, Ireland.
Doherty A; Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
Creedon M; Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
Houlihan E; Department of Clinical Microbiology, Galway University Hospital, Galway, Ireland.
Harrison M; Department of Respiratory Medicine, Galway University Hospital, Galway, Ireland.
Sheppard D; Department of Radiology, Galway University Hospital, Galway, Ireland.
Fleming C; Department of Infectious Diseases, Galway University Hospital, Galway, Ireland.
Fitzpatrick F; Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
Cormican M; Department of Clinical Microbiology, The Royal College of Surgeons in Ireland, Dublin, Ireland.

Ir Med J ; 114(2): 277, 2021 Feb 18.

Article in En | MEDLINE | ID: mdl-36331959

ABSTRACT

Presentation A 60-year-old male taking etanercept for ankylosing spondylitis was admitted to hospital with confusion and reduced level of consciousness over the preceding 24 hours. Diagnosis Magnetic Resonance Imaging (MRI) of his brain revealed pyogenic ventriculitis, and Escherichia coli was cultured from CSF. Treatment He required placement of an external ventricular drain and was treated with a prolonged course of intravenous ceftriaxone. Conclusion To our knowledge, this is the first reported case of spontaneous Gram-negative bacillary meningitis in a patient on anti-tumour necrosis factor (TNF)-alpha therapy, highlighting the risk of rare but serious infections associated with this class of medication.

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Database: MEDLINE Language: En Year: 2021 Type: Article

Database: MEDLINE Language: En Year: 2021 Type: Article