XCL1, a serum biomarker in neurological diseases; HTLV-1-associated myelopathy and multiple sclerosis.
Microb Pathog
; 174: 105962, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-36572194
ABSTRACT
The XCL1-XCR1 axis has a potential role in the recruitment of immune cells to the site of inflammation. The present study aimed to examine the relation of XCL1 serum levels with Multiple sclerosis (MS) and HTLV-1-associated myelopathy (HAM), as chronic inflammatory diseases of the central nervous system (CNS). DNA was extracted to evaluate HTLV-1 proviral load (PVL) using real-time PCR. Serum levels of XCL1 was determined by using an ELISA assay. The serum level of XCL1 was significantly higher in patients with HAM than that of asymptomatic carriers (ACs) and healthy controls (HCs) (p < 0.001 and p < 0.0001, respectively) and was also higher in MS patients compared to HCs (p < 0.0001). Moreover, the concentration of XCL1 serum level was significantly different between the ACs and HCs group (p < 0.0001). In conclusion, increased expression of XCL1 might contribute to the migration of autoreactive T cells to the central nervous system and play a critical role in the development and pathogenesis of inflammatory neurological diseases including HAM and MS.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Human T-lymphotropic virus 1
/
Paraparesis, Tropical Spastic
/
Chemokines, C
/
Multiple Sclerosis
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Year:
2023
Type:
Article