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Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases.
Suzuki, Kensuke; Tajima, Masaki; Tokumaru, Yosuke; Oshiro, Yuya; Nagata, Satoshi; Kamada, Haruhiko; Kihara, Miho; Nakano, Kohei; Honjo, Tasuku; Ohta, Akio.
Affiliation
  • Suzuki K; Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan.
  • Tajima M; Pharmaceutical R&D Division, Meiji Seika Pharma Co. Ltd., Tokyo 104-8002, Japan.
  • Tokumaru Y; Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan.
  • Oshiro Y; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  • Nagata S; Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan.
  • Kamada H; Pharmaceutical R&D Division, Meiji Seika Pharma Co. Ltd., Tokyo 104-8002, Japan.
  • Kihara M; Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan.
  • Nakano K; Pharmaceutical R&D Division, Meiji Seika Pharma Co. Ltd., Tokyo 104-8002, Japan.
  • Honjo T; Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki 567-0085, Japan.
  • Ohta A; Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki 567-0085, Japan.
Sci Immunol ; 8(79): eadd4947, 2023 01 13.
Article in En | MEDLINE | ID: mdl-36638191
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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2023 Type: Article