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An HPA-1a-positive platelet-depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo-controlled, single-center, phase 1/2 proof-of-concept study.
Geisen, Christof; Kjaer, Mette; Fleck, Erika; Skogen, Bjorn; Armstrong, Róisín; Behrens, Frank; Bhagwagar, Zubin; Braeuninger, Susanne; Mortberg, Anette; Olsen, Klaus Juel; Gastón Schäfer, Stephan Martin; Walter, Carmen; Seifried, Erhard; Wikman, Agneta; Kjeldsen-Kragh, Jens; Koehm, Michaela.
Affiliation
  • Geisen C; Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Frankfurt am Main, Germany.
  • Kjaer M; UiT - The Arctic University of Norway, Hammerfest, Norway; Finnmark Hospital Trust, Hammerfest, Norway.
  • Fleck E; Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Frankfurt am Main, Germany.
  • Skogen B; Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway.
  • Armstrong R; Rallybio, New Haven, Connecticut, USA.
  • Behrens F; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.
  • Bhagwagar Z; Rallybio, New Haven, Connecticut, USA.
  • Braeuninger S; Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Frankfurt am Main, Germany.
  • Mortberg A; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; CLINTEC, Karolinska Institutet, Stockholm, Sweden.
  • Olsen KJ; Larix A/S, Herlev, Denmark.
  • Gastón Schäfer SM; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.
  • Walter C; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.
  • Seifried E; Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Frankfurt am Main, Germany.
  • Wikman A; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; CLINTEC, Karolinska Institutet, Stockholm, Sweden.
  • Kjeldsen-Kragh J; Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Immunology and Transfusion Medicine, University and Regional Laboratories, Lund, Sweden. Electronic address: jkk@jkkmedical.com.
  • Koehm M; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.
J Thromb Haemost ; 21(4): 838-849, 2023 04.
Article in En | MEDLINE | ID: mdl-36696185
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Full text: 1 Database: MEDLINE Main subject: Antigens, Human Platelet / Thrombocytopenia, Neonatal Alloimmune Type of study: Clinical_trials / Diagnostic_studies Limits: Female / Humans / Male / Newborn / Pregnancy Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Antigens, Human Platelet / Thrombocytopenia, Neonatal Alloimmune Type of study: Clinical_trials / Diagnostic_studies Limits: Female / Humans / Male / Newborn / Pregnancy Language: En Year: 2023 Type: Article