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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr, Joshua N; Saul, Dominik; Doolittle, Madison L; Kaur, Japneet; Rowsey, Jennifer L; Vos, Stephanie J; Froemming, Mitchell N; Lagnado, Anthony B; Zhu, Yi; Weivoda, Megan; Ikeno, Yuji; Pignolo, Robert J; Niedernhofer, Laura J; Robbins, Paul D; Jurk, Diana; Passos, João F; LeBrasseur, Nathan K; Tchkonia, Tamara; Kirkland, James L; Monroe, David G; Khosla, Sundeep.
Affiliation
  • Farr JN; Robert and Arlene Kogod Center on Aging.
  • Saul D; Division of Endocrinology.
  • Doolittle ML; Department of Physiology and Biomedical Engineering, and.
  • Kaur J; Robert and Arlene Kogod Center on Aging.
  • Rowsey JL; Division of Endocrinology.
  • Vos SJ; Robert and Arlene Kogod Center on Aging.
  • Froemming MN; Division of Endocrinology.
  • Lagnado AB; Robert and Arlene Kogod Center on Aging.
  • Zhu Y; Division of Endocrinology.
  • Weivoda M; Robert and Arlene Kogod Center on Aging.
  • Ikeno Y; Division of Endocrinology.
  • Pignolo RJ; Robert and Arlene Kogod Center on Aging.
  • Niedernhofer LJ; Division of Endocrinology.
  • Robbins PD; Robert and Arlene Kogod Center on Aging.
  • Jurk D; Division of Endocrinology.
  • Passos JF; Robert and Arlene Kogod Center on Aging.
  • LeBrasseur NK; Department of Physiology and Biomedical Engineering, and.
  • Tchkonia T; Robert and Arlene Kogod Center on Aging.
  • Kirkland JL; Department of Physiology and Biomedical Engineering, and.
  • Monroe DG; Department of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Khosla S; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
J Clin Invest ; 133(8)2023 04 17.
Article in En | MEDLINE | ID: mdl-36809340
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Full text: 1 Database: MEDLINE Main subject: Aging / Cellular Senescence Type of study: Prognostic_studies Limits: Animals Language: En Year: 2023 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Aging / Cellular Senescence Type of study: Prognostic_studies Limits: Animals Language: En Year: 2023 Type: Article