Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example.
Semin Immunol
; 66: 101730, 2023 03.
Article
in En
| MEDLINE
| ID: mdl-36827760
ABSTRACT
In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the MHC-binding motif or TCR contact residues in a peptide antigen, transforming the tolerance to self to autoreactivity. Mass spectrometry-based immunopeptidomics provides a valuable mechanism for identifying MHC ligands that contain PTMs and can thus provide valuable insights into pathogenesis and therapeutics of autoimmune diseases. A plethora of PTMs have been implicated in this process, and this review highlights their formation and identification.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Diabetes Mellitus, Type 1
Limits:
Humans
Language:
En
Year:
2023
Type:
Article