The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer.

Varizhuk, Irina V; Tsvetkov, Vladimir B; Toropygin, Ilya Yu; Stomakhin, Andrey A; Kolganova, Natalia A; Surzhikov, Sergei A; Timofeev, Edward N

Varizhuk, Irina V; Tsvetkov, Vladimir B; Toropygin, Ilya Yu; Stomakhin, Andrey A; Kolganova, Natalia A; Surzhikov, Sergei A; Timofeev, Edward N.

Affiliation

Varizhuk IV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Tsvetkov VB; Federal Research and Clinical Center of Physical-Chemical Medicine, 119435 Moscow, Russia.
Toropygin IY; Institute of Biodesign and Complex System Modeling, Sechenov First Moscow State Medical University, 119146 Moscow, Russia.
Stomakhin AA; Department of Proteomics, V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119832, Russia.
Kolganova NA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Surzhikov SA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Timofeev EN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Pharmaceutics ; 15(2)2023 Feb 10.

Article in En | MEDLINE | ID: mdl-36839926