Chronic Trypanosoma cruzi infection activates the TWEAK/Fn14 axis in cardiac myocytes and fibroblasts driving structural and functional changes that affect the heart.

Santamaría, Miguel H; Ríos, Luisa Delgado; Corral, Ricardo S

Santamaría, Miguel H; Ríos, Luisa Delgado; Corral, Ricardo S.

Affiliation

Santamaría MH; Laboratorio de Biología Experimental, Centro de Estudios Metabólicos, Santander, Cantabria, Spain.
Ríos LD; Laboratorio de Biología Experimental, Centro de Estudios Metabólicos, Santander, Cantabria, Spain.
Corral RS; Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP, CONICET-GCBA), Servicio de Parasitología-Chagas, Hospital de Niños "Dr. Ricardo Gutiérrez", Buenos Aires, Argentina. Electronic address: ricardocorral@conicet.gov.ar.

Exp Parasitol ; 248: 108491, 2023 May.

Article in En | MEDLINE | ID: mdl-36841467

Subject(s)

Chagas Disease; Heart Diseases; Mice; Animals; Myocytes, Cardiac; TWEAK Receptor/metabolism; Mice, Inbred C57BL; NF-kappa B/metabolism; Tumor Necrosis Factor-alpha/metabolism; Inflammation; Fibroblasts; Heart Diseases/metabolism; Hypertrophy/metabolism

Key words

Adverse remodeling; Chagas heart disease; Inflammation; TWEAK/Fn14 axis; Trypanosoma cruzi

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Full text: 1 Database: MEDLINE Main subject: Chagas Disease / Heart Diseases Limits: Animals Language: En Year: 2023 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Chagas Disease / Heart Diseases Limits: Animals Language: En Year: 2023 Type: Article