Plasma cell-derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression.

Jibril, Aisha; Hellmich, Charlotte; Wojtowicz, Edyta E; Hampton, Katherine; Maynard, Rebecca; De Silva, Ravindu; Fowler-Shorten, Dominic J; Mistry, Jayna J; Moore, Jamie A; Bowles, Kristian M; Rushworth, Stuart A

Jibril, Aisha; Hellmich, Charlotte; Wojtowicz, Edyta E; Hampton, Katherine; Maynard, Rebecca; De Silva, Ravindu; Fowler-Shorten, Dominic J; Mistry, Jayna J; Moore, Jamie A; Bowles, Kristian M; Rushworth, Stuart A.

Affiliation

Jibril A; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Hellmich C; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Wojtowicz EE; Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.
Hampton K; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Maynard R; Earlham Institute, Norwich Research Park, Norwich, United Kingdom.
De Silva R; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Fowler-Shorten DJ; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Mistry JJ; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Moore JA; Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.
Bowles KM; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Rushworth SA; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.

Blood ; 141(25): 3065-3077, 2023 06 22.

Article in En | MEDLINE | ID: mdl-36888932

Subject(s)

Multiple Myeloma; Animals; Mice; Multiple Myeloma/metabolism; Plasma Cells/pathology; Macrophages/metabolism; DNA, Mitochondrial/genetics; Disease Progression; Tumor Microenvironment

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