Compounds isolated from the pericarp of Zanthoxylum bungeanum and inhibitory activity against LPS-induced NO production in RAW264.7.
J Asian Nat Prod Res
; 25(10): 1012-1020, 2023 Oct.
Article
in En
| MEDLINE
| ID: mdl-36916389
ABSTRACT
Seventeen compounds were isolated and identified from the ethyl acetate part of Zanthoxylum bungeanum Maxim., including one new compound 18-acetyloxyneocryptotanshinone (1) and 16 known compounds (2-17). Their structures were elucidated by extensive spectroscopy. The absolute configuration of 1 was confirmed by electronic circular dichroism (ECD). All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, of which 1 and 10 exhibited the most significant inhibitory effect, with IC50 of 17.29 and 10.27 µM, respectively.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Zanthoxylum
Language:
En
Year:
2023
Type:
Article