Recombinant measles virus expressing prefusion spike protein stabilized by six rather than two prolines is more efficacious against SARS-CoV-2 infection.

Zhang, Yuexiu; Lu, Mijia; Thongpan, Ilada; Xu, Jiayu; Kc, Mahesh; Dravid, Piyush; Trivedi, Sheetal; Sharma, Himanshu; Liang, Xueya; Kapoor, Amit; Peeples, Mark E; Li, Jianrong

Zhang, Yuexiu; Lu, Mijia; Thongpan, Ilada; Xu, Jiayu; Kc, Mahesh; Dravid, Piyush; Trivedi, Sheetal; Sharma, Himanshu; Liang, Xueya; Kapoor, Amit; Peeples, Mark E; Li, Jianrong.

Affiliation

Zhang Y; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Lu M; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Thongpan I; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Xu J; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Kc M; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Dravid P; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Trivedi S; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Sharma H; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Liang X; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Kapoor A; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Peeples ME; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Li J; Infectious Disease Institute, The Ohio State University, Columbus, Ohio, USA.

J Med Virol ; 95(4): e28687, 2023 04.

Article in En | MEDLINE | ID: mdl-36941778

Subject(s)

COVID-19; Cricetinae; Animals; Humans; Mice; COVID-19/prevention & control; SARS-CoV-2/genetics; COVID-19 Vaccines; Pandemics; Spike Glycoprotein, Coronavirus/genetics; Antibodies, Neutralizing; Measles virus/genetics; Proline; Antibodies, Viral

Key words

SARS-CoV-2; immunogenicity; prefusion spike; recombinant measles virus

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