Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-&#954;B and Bcl2 signalling.

Khan, Adnan; Shal, Bushra; Ullah Khan, Ashraf; Ullah Shah, Kifayat; Saniya Zahra, Syeda; Ul Haq, Ihsan; Ud Din, Fakhar; Ali, Hussain; Khan, Salman

Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-κB and Bcl2 signalling.

Khan, Adnan; Shal, Bushra; Ullah Khan, Ashraf; Ullah Shah, Kifayat; Saniya Zahra, Syeda; Ul Haq, Ihsan; Ud Din, Fakhar; Ali, Hussain; Khan, Salman.

Affiliation

Khan A; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; DHQ Teaching Hospital Timergara, Lower Dir, KPK, Pakistan
Shal B; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmaceutical Sciences, Pak-Austria Fachho
Ullah Khan A; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Faculty of Pharmaceutical Sciences, Abasyn University, Pe
Ullah Shah K; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: kushah@qau.edu.pk.
Saniya Zahra S; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: Saniya166@gmail.com.
Ul Haq I; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: ihsn99@yahoo.com.
Ud Din F; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: fudin@qau.edu.pk.
Ali H; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: h.ali@qau.edu.pk.
Khan S; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: skhan@qau.edu.pk.

Int Immunopharmacol ; 118: 110046, 2023 May.

Article in En | MEDLINE | ID: mdl-36989890

Subject(s)

NF-kappa B; Neuralgia; Rats; Animals; Mice; Male; Vincristine/pharmacology; NF-kappa B/metabolism; Hyperalgesia/drug therapy; NF-E2-Related Factor 2/metabolism; Antioxidants/pharmacology; Antioxidants/therapeutic use; Hydrogen Peroxide; bcl-2-Associated X Protein; Neuralgia/chemically induced; Neuralgia/drug therapy; Neuralgia/metabolism; Cytokines/metabolism

Key words

Ajugarin-I; Apoptosis; NF-κB/Nrf2; Neuropathic pain; PC12 cells; Vincristine

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