Improving the detection of Angiostrongylus cantonensis in the brain tissues of mammalian hosts.
Acta Trop
; 242: 106917, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-37011831
ABSTRACT
Angiostrongylus cantonensis is an invasive nematode parasite that causes eosinophilic meningitis in many vertebrate hosts, including humans. This parasite is spreading rapidly through the six continents, with Europe being the final frontier. Sentinel surveillance may be a cost-effective strategy to monitor the pathogen's arrival to new geographical regions. Necropsy, followed by tissue digestion, is often used to recover helminth parasites from vertebrate host tissues, however, to detect brain parasites, this protocol is poorly utilized. Our brain digestion protocol is easily performed and 1) reduces false positivity and negativity, 2) provides accurate estimates of parasite burden and 3) helps establish a more precise prevalence. Early detection of A. cantonensis increases the efficacy of prevention, treatment, and disease control strategies for susceptible animal populations and humans.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Strongylida Infections
/
Angiostrongylus cantonensis
/
Meningitis
/
Nematoda
Type of study:
Diagnostic_studies
/
Guideline
/
Risk_factors_studies
/
Screening_studies
Limits:
Animals
/
Humans
Language:
En
Year:
2023
Type:
Article