Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii.
Bioorg Chem
; 135: 106512, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37027948
ABSTRACT
Twenty new ent-kaurane diterpenoids, wardiisins A-T (1-20), along with two previously undescribed artefactual compounds (21 and 22) and twelve known analogues (23-34), were isolated from the aerial part of Isodon wardii. Their structures were elucidated by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction, and most of them were found to bear unusual C-12 oxygenation. Compounds 4, 7, 8, 19, 20, 21 exhibited remarkable cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MDA-MB-231, and SW480, with IC50 values ranging from 0.3 to 5.2 µM. Moreover, 7 was found to induce G2/M cell cycle arrest and promote apoptosis in SW480 cell lines.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Isodon
/
Diterpenes, Kaurane
/
Diterpenes
/
Antineoplastic Agents
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Year:
2023
Type:
Article