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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Weinstock, Joshua S; Gopakumar, Jayakrishnan; Burugula, Bala Bharathi; Uddin, Md Mesbah; Jahn, Nikolaus; Belk, Julia A; Bouzid, Hind; Daniel, Bence; Miao, Zhuang; Ly, Nghi; Mack, Taralynn M; Luna, Sofia E; Prothro, Katherine P; Mitchell, Shaneice R; Laurie, Cecelia A; Broome, Jai G; Taylor, Kent D; Guo, Xiuqing; Sinner, Moritz F; von Falkenhausen, Aenne S; Kääb, Stefan; Shuldiner, Alan R; O'Connell, Jeffrey R; Lewis, Joshua P; Boerwinkle, Eric; Barnes, Kathleen C; Chami, Nathalie; Kenny, Eimear E; Loos, Ruth J F; Fornage, Myriam; Hou, Lifang; Lloyd-Jones, Donald M; Redline, Susan; Cade, Brian E; Psaty, Bruce M; Bis, Joshua C; Brody, Jennifer A; Silverman, Edwin K; Yun, Jeong H; Qiao, Dandi; Palmer, Nicholette D; Freedman, Barry I; Bowden, Donald W; Cho, Michael H; DeMeo, Dawn L; Vasan, Ramachandran S; Yanek, Lisa R; Becker, Lewis C; Kardia, Sharon L R; Peyser, Patricia A.
Affiliation
  • Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Gopakumar J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Burugula BB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Uddin MM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Jahn N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Belk JA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Bouzid H; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Daniel B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Miao Z; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Ly N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Mack TM; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
  • Luna SE; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Prothro KP; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
  • Mitchell SR; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Broome JG; University of Washington, Seattle, WA, USA.
  • Taylor KD; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Guo X; University of Washington, Seattle, WA, USA.
  • Sinner MF; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.
  • von Falkenhausen AS; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Kääb S; Institute for Translational Genomics and Populations Sciences, Lundquist Institute, Torrance, CA, USA.
  • Shuldiner AR; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • O'Connell JR; Lundquist Institute, Torrance, CA, USA.
  • Lewis JP; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
  • Boerwinkle E; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany.
  • Barnes KC; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
  • Chami N; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany.
  • Kenny EE; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
  • Loos RJF; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany.
  • Fornage M; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.
  • Hou L; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.
  • Lloyd-Jones DM; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.
  • Redline S; University of Maryland, Baltimore, MD, USA.
  • Cade BE; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  • Psaty BM; University of Texas Health at Houston, Houston, TX, USA.
  • Bis JC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Brody JA; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Silverman EK; The Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.
  • Yun JH; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Qiao D; Institute for Genomic Health, New York, NY, USA.
  • Palmer ND; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Freedman BI; The Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.
  • Bowden DW; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Cho MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • DeMeo DL; University of Texas Health at Houston, Houston, TX, USA.
  • Vasan RS; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Yanek LR; Department of Preventive Medicine, Northeastern University, Chicago, IL, USA.
  • Becker LC; Department of Preventive Medicine, Northeastern University, Chicago, IL, USA.
  • Kardia SLR; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Peyser PA; Harvard Medical School, Boston, MA, USA.
Nature ; 616(7958): 755-763, 2023 04.
Article in En | MEDLINE | ID: mdl-37046083
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Full text: 1 Database: MEDLINE Main subject: Hematopoietic Stem Cells / Clonal Hematopoiesis Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Hematopoietic Stem Cells / Clonal Hematopoiesis Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Year: 2023 Type: Article