Tartaric acid induces toxicity in Madin-Darby canine kidney cells, but not human kidney-2 cells in vitro, and is prevented by organic anion transporter inhibition and human OAT-4 transfection.

Coyne, Sean R; Landry, Greg M

Coyne, Sean R; Landry, Greg M.

Affiliation

Coyne SR; Department of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA.
Landry GM; Department of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA.

J Vet Emerg Crit Care (San Antonio) ; 33(3): 298-304, 2023.

Article in En | MEDLINE | ID: mdl-37087614

Subject(s)

Organic Anion Transporters; Humans; Animals; Dogs; Madin Darby Canine Kidney Cells; Organic Anion Transporters/genetics; Organic Anion Transporters/metabolism; Avena; Probenecid/pharmacology; Probenecid/metabolism; Kidney/metabolism; Transfection/veterinary

Key words

acute kidney injury; dogs; grape toxicity; toxicant

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Full text: 1 Database: MEDLINE Main subject: Organic Anion Transporters Limits: Animals / Humans Language: En Year: 2023 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Organic Anion Transporters Limits: Animals / Humans Language: En Year: 2023 Type: Article