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Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.
Ikeda, Zenichi; Kamei, Taku; Sasaki, Yusuke; Reynolds, Matthew; Sakai, Nozomu; Yoshikawa, Masato; Tawada, Michiko; Morishita, Nao; Dougan, Douglas R; Chen, Chien-Hung; Levin, Irena; Zou, Hua; Kuno, Masako; Arimura, Naoto; Kikukawa, Yusuke; Kondo, Mitsuyo; Tohyama, Kimio; Sato, Kenjiro.
Affiliation
  • Ikeda Z; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kamei T; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sasaki Y; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Reynolds M; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sakai N; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yoshikawa M; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Tawada M; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Morishita N; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Dougan DR; Structural Biology, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.
  • Chen CH; Structural Biology, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.
  • Levin I; Structural Biology, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.
  • Zou H; Structural Biology, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.
  • Kuno M; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Arimura N; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kikukawa Y; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kondo M; Discovery Biology, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan.
  • Tohyama K; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sato K; Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
J Med Chem ; 66(9): 6354-6371, 2023 05 11.
Article in En | MEDLINE | ID: mdl-37120845
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Full text: 1 Database: MEDLINE Main subject: Complement C1s / Complement Activation Limits: Humans Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Complement C1s / Complement Activation Limits: Humans Language: En Year: 2023 Type: Article