Small Molecules Targeting DNA Polymerase Theta (POLÎ¸) as Promising Synthetic Lethal Agents for Precision Cancer Therapy.

Pismataro, Maria Chiara; Astolfi, Andrea; Barreca, Maria Letizia; Pacetti, Martina; Schenone, Silvia; Bandiera, Tiziano; Carbone, Anna; Massari, Serena.

Affiliation

Pismataro MC; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Astolfi A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Barreca ML; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Pacetti M; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Schenone S; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy.
Bandiera T; D3 PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Carbone A; Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy.
Massari S; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.

J Med Chem ; 66(10): 6498-6522, 2023 05 25.

Article in En | MEDLINE | ID: mdl-37134182

Subject(s)

DNA-Directed DNA Polymerase; Neoplasms; DNA-Directed DNA Polymerase/chemistry; DNA-Directed DNA Polymerase/genetics; DNA-Directed DNA Polymerase/metabolism; DNA Helicases/genetics; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Synthetic Lethal Mutations; Neoplasms/drug therapy; DNA Polymerase theta