Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer.

Kolganova, Natalia A; Tsvetkov, Vladimir B; Stomakhin, Andrey A; Surzhikov, Sergei A; Timofeev, Edward N; Varizhuk, Irina V

Kolganova, Natalia A; Tsvetkov, Vladimir B; Stomakhin, Andrey A; Surzhikov, Sergei A; Timofeev, Edward N; Varizhuk, Irina V.

Affiliation

Kolganova NA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Tsvetkov VB; Federal Research and Clinical Center of Physical-Chemical Medicine, 119435 Moscow, Russia.
Stomakhin AA; Institute of Biodesign and Complex System Modeling, Sechenov First Moscow State Medical University, 119146 Moscow, Russia.
Surzhikov SA; A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991 Moscow, Russia.
Timofeev EN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Varizhuk IV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Int J Mol Sci ; 24(9)2023 May 07.

Article in En | MEDLINE | ID: mdl-37176113

Subject(s)

Aptamers, Nucleotide; G-Quadruplexes; Aptamers, Nucleotide/chemistry; Thrombin/metabolism; Anticoagulants/chemistry; Deoxyguanosine

Key words

G-quadruplex; alpha-deoxyguanosine; alpha-thrombin; anticoagulant activity; aptamer; circular dichroism; molecular dynamics; peptide-oligonucleotide conjugate

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