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Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.
Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo.
Affiliation
  • Rullo M; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • La Spada G; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Miniero DV; Dept. of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.
  • Gottinger A; Dept. of Biology and Biotechnology, University of Pavia, via Ferrata 9, 27100, Pavia, Italy.
  • Catto M; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Delre P; CNR, Institute of Crystallography, 70126, Bari, Italy.
  • Mastromarino M; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy.
  • Latronico T; Dept. of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.
  • Marchese S; Dept. of Biology and Biotechnology, University of Pavia, via Ferrata 9, 27100, Pavia, Italy.
  • Mangiatordi GF; CNR, Institute of Crystallography, 70126, Bari, Italy.
  • Binda C; Dept. of Biology and Biotechnology, University of Pavia, via Ferrata 9, 27100, Pavia, Italy.
  • Linusson A; Department of Chemistry, Umeå University, 90187, Umeå, Sweden.
  • Liuzzi GM; Dept. of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.
  • Pisani L; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: leonardo.pisani@uniba.it.
Eur J Med Chem ; 255: 115352, 2023 Jul 05.
Article in En | MEDLINE | ID: mdl-37178666
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Full text: 1 Database: MEDLINE Main subject: Neuroprotection / Neuroblastoma Limits: Humans Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Neuroprotection / Neuroblastoma Limits: Humans Language: En Year: 2023 Type: Article