Polysaccharides from Oudemansiella radicata residues attenuate carbon tetrachloride-induced liver injury.
Int J Biol Macromol
; 242(Pt 2): 124823, 2023 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-37178886
ABSTRACT
The present work aimed to investigate the potential hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). Our results demonstrated that RPS showed significantly protective effects against carbon tetrachloride (CCl4)-induced liver injury, and the possible mechanisms may be related with the predominant bioactivities of RPS containing anti-oxidation by activating the Nrf2 signal pathways, anti-inflammation by inhibiting NF-κB signal pathways and reducing the release of inflammatory cytokines, anti-apoptosis by regulating Bcl-2/Bax pathway, and anti-fibrosis by inhibiting the expressions of TGF-ß1, Hyp and α-SMA, respectively. These findings suggested that RPS, a typical ß-type glycosidic pyranose, could be used as a promising diet supplement or medication for the adjunctive treatment of hepatic diseases, and also contributed to promoting the recyclable utilization of mushroom residues.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Agaricales
/
Chemical and Drug Induced Liver Injury, Chronic
Language:
En
Year:
2023
Type:
Article