Elevated complement C3 and increased CD8 and type 1 helper lymphocyte T populations in patients with post-COVID-19 condition.
Cytokine
; 169: 156295, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37453328
ABSTRACT
BACKGROUND:
Biological markers associated to post-COVID-19 condition (PCC) have not been clearly identified.METHODS:
Eighty-two patients attending our post-COVID-19 outpatient clinic were recruited and classified as fully recovered (40.2%) or presenting with PCC (59.8%). Clinical and radiological data, laboratory markers, cytokines, and lymphocyte populations were analyzed.RESULTS:
Median number of days after hospitalization was 78.5 [p25-p75 60-93] days. PCC was significantly more frequent in women, in patients with a previously critical COVID-19, and in those with two or more comorbidities. No differences were found in lymphocyte counts, ferritin, C-reactive protein, D-dimer or sCD25, IL-1ß, IL-1Ra, IL-6, CXCL8, IL-17A, IL-18, IL-22, IFN-γ, TNF-α, and IL-10 cytokines levels. PCC patients showed significantly higher levels of complement factor C3 than fully recovered patients median C3 128 mg/dL [p25-p75107-135] vs 111 mg/dL [p25-p75 100-125] (p =.005), respectively. In the flow cytometry assessment of peripheral blood lymphocyte subpopulations, PCC patients showed significantly increased CD8 populations compared to fully recovered patients median CD8 529 [p25-p75 384-683] vs 370/mm3 [p25-p75280-523], p =.007. When type 1, 2, 17/22, and 17.1 helper and follicular T lymphocyte subpopulations were analyzed, the frequency of Th1 was significantly higher in PCC patients compared to fully recovered patients (30% vs 38.5%, p =.028).CONCLUSION:
Patients with a post-COVID-19 condition showed significantly increased immunological parameters of inflammation (complement factor C3 and CD8 and Th1 T lymphocyte populations) compared to fully recovered patients. These parameters could be used as biological markers of this condition.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Complement C3
/
COVID-19
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Year:
2023
Type:
Article