Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs.

Kruglyak, Kristina M; O'Kell, Allison L; Cohen, Todd A; Marshall, Maggie A; Ruiz-Perez, Carlos A; Marass, Francesco; Tynan, John A; Hicks, Susan C; Lytle, Katherine M; Phelps-Dunn, Ashley; Brandstetter, Gina; Warren, Chelsea D; DiMarzio, Lauren R; Rosentel, Michelle C; Wong, Lilian K; McLennan, Lisa M; Rafalko, Jill M; Grosu, Daniel S; Chibuk, Jason; Chorny, Ilya; McCleary-Wheeler, Angela L; Flory, Andi; Tsui, Dana W Y

Kruglyak, Kristina M; O'Kell, Allison L; Cohen, Todd A; Marshall, Maggie A; Ruiz-Perez, Carlos A; Marass, Francesco; Tynan, John A; Hicks, Susan C; Lytle, Katherine M; Phelps-Dunn, Ashley; Brandstetter, Gina; Warren, Chelsea D; DiMarzio, Lauren R; Rosentel, Michelle C; Wong, Lilian K; McLennan, Lisa M; Rafalko, Jill M; Grosu, Daniel S; Chibuk, Jason; Chorny, Ilya; McCleary-Wheeler, Angela L; Flory, Andi; Tsui, Dana W Y.

Affiliation

Kruglyak KM; Information Technology, PetDx, La Jolla, CA 92037, USA.
O'Kell AL; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Cohen TA; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Marshall MA; Information Technology, PetDx, La Jolla, CA 92037, USA.
Ruiz-Perez CA; Information Technology, PetDx, La Jolla, CA 92037, USA.
Marass F; Information Technology, PetDx, La Jolla, CA 92037, USA.
Tynan JA; Research Programs, PetDx, La Jolla, CA 92037, USA.
Hicks SC; Analytical Production, PetDx, La Jolla, CA 92037, USA.
Lytle KM; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Phelps-Dunn A; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Brandstetter G; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Warren CD; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
DiMarzio LR; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Rosentel MC; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Wong LK; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
McLennan LM; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Rafalko JM; Research Programs, PetDx, La Jolla, CA 92037, USA.
Grosu DS; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Chibuk J; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
Chorny I; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.
McCleary-Wheeler AL; Information Technology, PetDx, La Jolla, CA 92037, USA.
Flory A; Research Programs, PetDx, La Jolla, CA 92037, USA.
Tsui DWY; Medical & Clinical Affairs, PetDx, La Jolla, CA 92037, USA.

Vet Sci ; 10(7)2023 Jul 11.

Article in En | MEDLINE | ID: mdl-37505860

Key words

age-related clonal hematopoiesis (ARCH); cancer; canine; clonal expansion; clonal hematopoiesis of indeterminate potential (CHIP); copy number variant (CNV); germline; liquid biopsy; next-generation sequencing (NGS); somatic

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