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Comparable bio-evaluation of curcumin and chitosan-encapsulated curcumin nanoparticles against the reprotoxic potential of fenpropathrin pyrethroid in rats: Genomic and morphometric prospectives.
Mohamed, Amany Abdel-Rahman; Behairy, Amany; Abd El-Hakim, Yasmina M; Metwally, Mohamed M M; Khamis, Tarek; Abuzahrah, Samah S; Abdelhamid, Ahmed E; Alqahtani, Leena S; Essawi, Walaa M; Alotaibi, Badriyah S; Alosaimi, Manal; Ahmed El-Shaer, Rehab Ahmed; Awad, Marwa Mahmoud; El-Shetry, Eman S.
Affiliation
  • Mohamed AA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Behairy A; Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Sharkia, Egypt.
  • Abd El-Hakim YM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Metwally MMM; Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt.
  • Khamis T; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt; Laboratory of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt.
  • Abuzahrah SS; Department of Biological Sciences, College of Science, University of Jeddah, Saudi Arabia, 21959, Saudi Arabia.
  • Abdelhamid AE; Polymers & Pigments Department, National Research Centre, 33 El-Buhouth St. Dokki, Giza, 12622, Egypt.
  • Alqahtani LS; Department of Biochemistry, College of Science, University of Jeddah, Jeddah, 23445, Saudi Arabia.
  • Essawi WM; Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan, 81528, Egypt.
  • Alotaibi BS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. Electronic address: bsalotaibi@pnu.edu.sa.
  • Alosaimi M; Department of Basic Health Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
  • Ahmed El-Shaer RA; Physiology Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt.
  • Awad MM; Physiology Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt.
  • El-Shetry ES; Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, 44511, Egypt.
Food Chem Toxicol ; 179: 113977, 2023 Sep.
Article in En | MEDLINE | ID: mdl-37532170
ABSTRACT
This study delves into the intricate exploration of potential toxic effects resulting from subchronic exposure to fenpropathrin (FNP) on the reproductive system of male SD rats. Adding to the novelty, our study undertakes a pioneering comparison of the effects of curcumin (CUR) and curcumin-encapsulated chitosan nanoparticles (CS.CUR.NPs) on these toxic effects. The study involved a cohort of sixty male SD rats (six groups) vehicle control, CUR, Cs.CUR.NPs, FNP, and two combination groups (FNP with CUR or Cs.CUR.NPs). The synthesized Cs.CUR.NPs nanoparticles underwent meticulous characterization using Fourier Infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM). The findings revealed that FNP caused oxidative stress, sperm abnormalities, reduced motility and sperm count FNP decreased serum LH, FSH, 17-ß estradiol, and testosterone levels. FNP downregulated the mRNA expression of the spermatogenesis and steroidogenesis-related genes, While, downregulated hypothalamic KISS-1 and KISS-1r expression. Histopathological alterations were assessed and scored. Surprisingly, the treatment with CUR and Cs.CUR.NPs exhibited remarkable restorative effects on semen quality, sex hormone levels, antioxidant capacity, and mRNA expression of the targeted genes. Notably, Cs.CUR.NPs displayed superior properties when compared to CUR. Nevertheless, further research is imperative to evaluate their efficacy across various bodily tissues.
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Full text: 1 Database: MEDLINE Main subject: Pyrethrins / Curcumin / Chitosan / Nanoparticles Type of study: Observational_studies Limits: Animals Language: En Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrethrins / Curcumin / Chitosan / Nanoparticles Type of study: Observational_studies Limits: Animals Language: En Year: 2023 Type: Article