Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.

Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai, Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G

Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai, Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G.

Affiliation

Ren W; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Vairin R; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Ward JD; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Francis R; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
VanNatta J; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Bai R; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States.
Tankoano PE; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Deng Y; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Hamel E; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States.
Trawick ML; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States.
Pinney KG; Department of Chemistry and Biochemistry, Baylor University, One Bear Place, No. 97348, Waco, TX 76798-7348, United States. Electronic address: Kevin_Pinney@baylor.edu.

Bioorg Med Chem ; 92: 117400, 2023 09 07.

Article in En | MEDLINE | ID: mdl-37556912

Subject(s)

Antineoplastic Agents; Humans; Antineoplastic Agents/chemistry; Cell Line, Tumor; Tubulin/metabolism; Molecular Docking Simulation; Drug Screening Assays, Antitumor; Structure-Activity Relationship; Indoles/chemistry; Colchicine/pharmacology; Tubulin Modulators/pharmacology; Cell Proliferation; Molecular Structure

Key words

Friedel-Crafts alkylation; Inhibition of tubulin polymerization; Oxetane

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