Your browser doesn't support javascript.
loading
Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).
Baker, Laura D; Snyder, Heather M; Espeland, Mark A; Whitmer, Rachel A; Kivipelto, Miia; Woolard, Nancy; Katula, Jeffrey; Papp, Kathryn V; Ventrelle, Jennifer; Graef, Sarah; Hill, Marcus A; Rushing, Scott; Spell, Julia; Lovato, Laura; Felton, Deborah; Williams, Benjamin J; Ghadimi Nouran, Mina; Raman, Rema; Ngandu, Tiia; Solomon, Alina; Wilmoth, Sharon; Cleveland, Maryjo L; Williamson, Jeff D; Lambert, Katherine L; Tomaszewski Farias, Sarah; Day, Claire E; Tangney, Christy C; Gitelman, Darren R; Matongo, Olivia; Reynolds, Terrianne; Pavlik, Valory N; Yu, Melissa M; Alexander, Ashley S; Elbein, Richard; McDonald, Ann Marie; Salloway, Stephen; Wing, Rena R; Antkowiak, Susan; Morris, Martha Clare; Carrillo, Maria C.
Affiliation
  • Baker LD; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Snyder HM; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Espeland MA; Wake Forest University School of Medicine, Department of Neurology, Winston Salem, North Carolina, USA.
  • Whitmer RA; Alzheimer's Association, Chicago, Illinois, USA.
  • Kivipelto M; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Woolard N; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Katula J; University of California Davis, Department of Public Health Sciences, Sacramento, California, USA.
  • Papp KV; Karolinska Institute, Division of Clinical Geriatrics, Center for Alzheimer Research, Stockholm, Sweden.
  • Ventrelle J; University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland.
  • Graef S; Imperial College London, School of Public Health, Ageing Epidemiology Research Unit, London, UK.
  • Hill MA; FINGERS Brain Health Institute, Stockholm, Sweden.
  • Rushing S; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Spell J; Wake Forest University, Department of Health and Exercise Science, Winston Salem, North Carolina, USA.
  • Lovato L; Brigham and Women's Hospital, Department of Neurology, Boston, Massachusetts, USA.
  • Felton D; Massachusetts General Hospital, Department of Neurology, Boston, Massachusetts, USA.
  • Williams BJ; Harvard Medical School, Department of Neurology, Boston, Massachusetts, USA.
  • Ghadimi Nouran M; Rush University Medical Center, Departments of Clinical Nutrition, and Family and Preventive Medicine, Chicago, Illinois, USA.
  • Raman R; Rush University Medical Center, Departments of Clinical Nutrition, and Family and Preventive Medicine, Chicago, Illinois, USA.
  • Ngandu T; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Solomon A; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Wilmoth S; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Cleveland ML; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Williamson JD; Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, North Carolina, USA.
  • Lambert KL; Wake Forest University School of Medicine, Department of Neurology, Winston Salem, North Carolina, USA.
  • Tomaszewski Farias S; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Day CE; University of Southern California, Alzheimer's Therapeutic Research Institute, San Diego, California, USA.
  • Tangney CC; Karolinska Institute, Division of Clinical Geriatrics, Center for Alzheimer Research, Stockholm, Sweden.
  • Gitelman DR; Finnish Institute for Health and Welfare, Department of Public Health and Welfare, Helsinki, Finland.
  • Matongo O; Karolinska Institute, Division of Clinical Geriatrics, Center for Alzheimer Research, Stockholm, Sweden.
  • Reynolds T; Imperial College London, School of Public Health, Ageing Epidemiology Research Unit, London, UK.
  • Pavlik VN; FINGERS Brain Health Institute, Stockholm, Sweden.
  • Yu MM; University of Eastern Finland, Institute of Clinical Medicine/Neurology, Kuopio, Finland.
  • Alexander AS; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Elbein R; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • McDonald AM; Wake Forest University School of Medicine, Department of Internal Medicine, Winston Salem, North Carolina, USA.
  • Salloway S; Alzheimer's Association, Western Carolina Chapter, Charlotte, North Carolina, USA.
  • Wing RR; University of California Davis, Department of Neurology, Sacramento, California, USA.
  • Antkowiak S; Alzheimer's Association, Northern California Northern Nevada Chapter, San Jose, California, USA.
  • Morris MC; University of Southern California, Alzheimer's Therapeutic Research Institute, San Diego, California, USA.
  • Carrillo MC; Advocate Health Care, Department of Behavioral Neurology, Downers Grove, Illinois, USA.
Alzheimers Dement ; 20(2): 769-782, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37776210
ABSTRACT

INTRODUCTION:

The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.

METHODS:

U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.

RESULTS:

U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing.

DISCUSSION:

U.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Cognitive Dysfunction Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Aged / Humans Language: En Year: 2024 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Cognitive Dysfunction Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Aged / Humans Language: En Year: 2024 Type: Article