Simultaneous analysis of carcinogenic N-nitrosamine impurities in metformin tablets using on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry.

Ishizaki, Atsushi; Ozawa, Kazutaka; Kataoka, Hiroyuki

Ishizaki, Atsushi; Ozawa, Kazutaka; Kataoka, Hiroyuki.

Affiliation

Ishizaki A; School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.
Ozawa K; School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.
Kataoka H; School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan. Electronic address: hkataoka@shujitsu.ac.jp.

J Chromatogr A ; 1710: 464416, 2023 Nov 08.

Article in En | MEDLINE | ID: mdl-37804578

Subject(s)

Nitrosamines; Tandem Mass Spectrometry; Humans; Chromatography, Liquid/methods; Tandem Mass Spectrometry/methods; Solid Phase Microextraction/methods; Pharmaceutical Preparations; Chromatography, High Pressure Liquid/methods

Key words

In-tube solid-phase microextraction; Liquid chromatographytandem mass spectrometry; Metformin; N-nitrosamines; Pharmaceutical impurities

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Tandem Mass Spectrometry / Nitrosamines Limits: Humans Language: En Year: 2023 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Tandem Mass Spectrometry / Nitrosamines Limits: Humans Language: En Year: 2023 Type: Article