Conformation state-specific monobodies regulate the functions of flexible proteins through conformation trapping.

Nakamura, Ibuki; Amesaka, Hiroshi; Hara, Mizuho; Yonezawa, Kento; Okamoto, Keisuke; Kamikubo, Hironari; Tanaka, Shun-Ichi; Matsuo, Takashi

Nakamura, Ibuki; Amesaka, Hiroshi; Hara, Mizuho; Yonezawa, Kento; Okamoto, Keisuke; Kamikubo, Hironari; Tanaka, Shun-Ichi; Matsuo, Takashi.

Affiliation

Nakamura I; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Nara, Japan.
Amesaka H; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Hara M; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Yonezawa K; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Nara, Japan.
Okamoto K; Center for Digital Green-innovation, Nara Institute of Science and Technology (NAIST), Nara, Japan.
Kamikubo H; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Tanaka SI; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Nara, Japan.
Matsuo T; Center for Digital Green-innovation, Nara Institute of Science and Technology (NAIST), Nara, Japan.

Protein Sci ; 32(12): e4813, 2023 Dec.

Article in En | MEDLINE | ID: mdl-37861467

Subject(s)

Carrier Proteins; Binding Sites; Crystallography, X-Ray; Protein Binding; Protein Conformation; Scattering, Small Angle; X-Ray Diffraction; Chromatography

Key words

SEC-SAXS; adenylate kinase; conformational change; monobody; protein-protein interaction (PPI); pyrene; synthetic binding protein

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