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Methotrexate-based PROTACs as DHFR-specific chemical probes.
Rana, Sandeep; Dranchak, Patricia; Dahlin, Jayme L; Lamy, Laurence; Li, Wenqing; Oliphant, Erin; Shrimp, Jonathan H; Rajacharya, Girish H; Tharakan, Ravi; Holland, David O; Whitten, Apryl S; Wilson, Kelli M; Singh, Pankaj K; Durum, Scott K; Tao, Dingyin; Rai, Ganesha; Inglese, James.
Affiliation
  • Rana S; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Dranchak P; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Dahlin JL; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Lamy L; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Li W; Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA.
  • Oliphant E; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Shrimp JH; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Rajacharya GH; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
  • Tharakan R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Holland DO; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Whitten AS; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
  • Wilson KM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Singh PK; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; OU Health Stephenson Center, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
  • Durum SK; Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA.
  • Tao D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Rai G; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA. Electronic address: bantukallug@mail.nih.gov.
  • Inglese J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA; Metabolic Medicine Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: jinglese@mail.nih.gov.
Cell Chem Biol ; 31(2): 221-233.e14, 2024 Feb 15.
Article in En | MEDLINE | ID: mdl-37875111
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Full text: 1 Database: MEDLINE Main subject: Folic Acid Antagonists / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Year: 2024 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Folic Acid Antagonists / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Year: 2024 Type: Article