Resiniferatoxin: Nature's Precision Medicine to Silence TRPV1-Positive Afferents.
Int J Mol Sci
; 24(20)2023 Oct 10.
Article
in En
| MEDLINE
| ID: mdl-37894723
ABSTRACT
Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was shown to restore continence in a subset of patients with idiopathic and neurogenic detrusor overactivity. RTX can also ablate sensory neurons as a "molecular scalpel" to achieve permanent analgesia. This targeted (intrathecal or epidural) RTX therapy holds great promise in cancer pain management. Intra-articular RTX is undergoing clinical trials to treat moderate-to-severe knee pain in patients with osteoarthritis. Similar targeted approaches may be useful in the management of post-operative pain or pain associated with severe burn injuries. The current state of this field is reviewed, from preclinical studies through veterinary medicine to clinical trials.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Diterpenes
/
Urinary Bladder, Overactive
Limits:
Humans
Language:
En
Year:
2023
Type:
Article