One-year lung function decline in sarcoidosis.
Respir Investig
; 62(1): 9-12, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37925884
ABSTRACT
BACKGROUND:
The definition of progressive pulmonary fibrosis is based on a 1-year lung function decline.OBJECTIVES:
To evaluate the epidemiology and clinical relevance of 1-year lung function decline in sarcoidosis.METHODS:
A retrospective observational study at a general sarcoidosis clinic.RESULTS:
Of the 198 patients, 42 (18.4 %) had a 1-year lung function decline (absolute 12-month decline in percentage predicted forced vital capacity [%FVC] of ≥5 % or percentage predicted diffusion capacity for carbon monoxide [%DLCO] of ≥10 %). A 1-year lung function decline was associated with a 2-year lung function decline (a relative 24-month decline in %FVC of ≥10 % or %DLCO of ≥15 %), which occurred in 13 (7.4 %) of the 175 patients with 24-month follow-up results. A 1-year lung function decline was not associated with survival; a 2-year lung function decline predicted mortality.CONCLUSIONS:
Compared with a 24-month decline, a 12-month decline in lung function did not predict worse survival in sarcoidosis.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pulmonary Fibrosis
/
Sarcoidosis
Limits:
Humans
Language:
En
Year:
2024
Type:
Article