Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.
Alzheimers Dement
; 20(2): 1350-1359, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-37984813
ABSTRACT
INTRODUCTION:
The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aß) over 15 years in a cohort of cognitively unimpaired older adults.METHODS:
PA and Aß measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aß. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aß relationship.RESULTS:
PA was not associated with brain Aß at baseline (ß = -0.001, p = 0.72) or over time (ß = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aß relationship over time (ß = 0.12, p = 0.73). Brain Aß levels did not predict PA trajectory (ß = -54.26, p = 0.59).DISCUSSION:
Our study did not identify a relationship between habitual PA and brain Aß levels. HIGHLIGHTS Physical activity levels did not predict brain amyloid beta (Aß) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aß relationship over time. Physical activity trajectories were not impacted by brain Aß levels.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Amyloid beta-Peptides
/
Alzheimer Disease
Limits:
Aged
/
Humans
Country/Region as subject:
Oceania
Language:
En
Year:
2024
Type:
Article