Shigella flexneri remodeling and consumption of host lipids during infection.
J Bacteriol
; 205(12): e0032023, 2023 12 19.
Article
in En
| MEDLINE
| ID: mdl-37991380
ABSTRACT
IMPORTANCE Bacterial pathogens have vastly distinct sites that they inhabit during infection. This requires adaptation due to changes in nutrient availability and antimicrobial stress. The bacterial surface is a primary barrier, and here, we show that the bacterial pathogen Shigella flexneri increases its surface decorations when it transitions to an intracellular lifestyle. We also observed changes in bacterial and host cell fatty acid homeostasis. Specifically, intracellular S. flexneri increased the expression of their fatty acid degradation pathway, while the host cell lipid pool was significantly depleted. Importantly, bacterial proliferation could be inhibited by fatty acid supplementation of host cells, thereby providing novel insights into the possible link between human malnutrition and susceptibility to S. flexneri.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Shigella flexneri
/
Bacterial Proteins
Limits:
Humans
Language:
En
Year:
2023
Type:
Article