Design, synthesis, and biological evaluation of novel tryptanthrin derivatives as selective acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.

Xia, Jucheng; Dong, Shuanghong; Yang, Lili; Wang, Fang; Xing, Siqi; Du, Jiyu; Li, Zeng

Xia, Jucheng; Dong, Shuanghong; Yang, Lili; Wang, Fang; Xing, Siqi; Du, Jiyu; Li, Zeng.

Affiliation

Xia J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Dong S; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Yang L; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Wang F; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Xing S; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Du J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China.
Li Z; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, PR China. Electronic address: lizeng@ahmu.edu.cn.

Bioorg Chem ; 143: 106980, 2024 Feb.

Article in En | MEDLINE | ID: mdl-38006789

Subject(s)

Alzheimer Disease; Cholinesterase Inhibitors; Quinazolines; Mice; Animals; Cholinesterase Inhibitors/pharmacology; Cholinesterase Inhibitors/therapeutic use; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Acetylcholinesterase/metabolism; Butyrylcholinesterase/metabolism; Molecular Docking Simulation; Amyloid beta-Peptides/metabolism; Drug Design; Structure-Activity Relationship; Molecular Structure

Key words

Acetylcholinesterase; Alzheimer's disease; Anti-neuroinflammation; Multitarget-directed ligand; Tryptanthrin derivatives

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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Cholinesterase Inhibitors / Alzheimer Disease Limits: Animals Language: En Year: 2024 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Cholinesterase Inhibitors / Alzheimer Disease Limits: Animals Language: En Year: 2024 Type: Article